Blocking VEGF Receptors inhibits Cancer Angiogenisis

VEGF - Vascular Endothelial Growth Factor

Flavanols have been shown to mediate VEGF and therefore provide potential anti-cancer benefits, although the precise signalling pathways have yet to be determined - see VEGF Abstracts...

The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumour cells and referred to as "tumour angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumour-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.

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